Meyd-873 !full! Page

Repeated‑dose toxicology in rodents (28 days) showed only mild, reversible hepatic enzyme elevations that normalized after a two‑week washout. No histopathological lesions were observed in the brain, heart, or kidneys.

| Phase | Design | Target Population | Primary Endpoint | Expected Milestones | |-------|--------|-------------------|------------------|---------------------| | (dose‑finding, safety) | Open‑label, 3‑plus‑3 escalation → expansion cohorts | KRAS‑G12D+ solid tumors (pancreatic, colorectal, NSCLC) with RAF‑DimerScore ≥ 2 | ORR (RECIST v1.1) + safety | IND filing Q3 2024 → First patient in Q1 2025 | | Phase 2b (confirmatory) | Randomized, double‑blind, MEYD‑873 + standard chemo vs. chemo alone | Same as above | PFS, OS, and biomarker‑driven subgroup analysis | Topline data Q4 2026 | | Phase 3 (global pivotal) | Multi‑regional, double‑blind | KRAS‑G12D+/RAF‑high metastatic pancreatic adenocarcinoma (primary) and KRAS‑G12D+ NSCLC (secondary) | OS superiority | NDA submission Q2 2029 | MEYD-873

MEYD‑873 simultaneously binds to two critical nodes in the : Repeated‑dose toxicology in rodents (28 days) showed only

Here’s a proper review of the JAV title , released under the Oba-chan (auntie/milf) sub-genre by the label 溜池ゴロー (Tameike Goro) . chemo alone | Same as above | PFS,

| Model | Outcome | Notes | |-------|---------|-------| | | > 10 µM off‑target activity (clean) | Confirms selectivity | | Mouse AML xenograft (NSG, MOLM‑13) | Tumor regression (complete remission in 4/8 mice) | Oral dosing, BID, 25 mg/kg | | Syngeneic pancreatic cancer (KPC) + anti‑PD‑1 | 78 % TGI, increased CD8⁺ infiltration | Demonstrates immune‑modulating potential | | Rat toxicology (28‑day repeat dose) | NOAEL = 100 mg/kg/day | No observable cardiac, hepatic, or CNS toxicity | | Pharmacokinetics (PK) | Oral bioavailability ≈ 55 % in dogs; half‑life ≈ 12 h | Supports BID oral regimen |